the big C


the big C
   American
   cancer
   The dread affliction which may lead to the big D:
    ... ailments are apt to be called by their own names or by superstitious shortened forms: arthritis, emphysema, cancer (or the Big C). (Johnson and Murray in Enright, 1985)

How not to say what you mean: A dictionary of euphemisms. . 2014.

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