out of your skull

out of your skull
   mentally unwell
   You may also be described as being out of your gourd, head, senses, tree, etc.:
    'You're fucked,' I said. 'You're out of your gourd.' (Turow, 1996)
    He's out of his skull... ready for certifying. (Bogarde, 1981)
    Lady Macbeth was... clearly out of her tree. (N. Evans, 1995 — and not after hiding in Birnham Wood)

How not to say what you mean: A dictionary of euphemisms. . 2014.

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